Arsenal have rung the changes after their Europa League victory over AC Milan.
David Ospina, Calum Chambers, Laurent Koscielny, Aaron Ramsey, Jack Wilshere and Danny Welbeck have all been replaced in the starting XI after the 2-0 win at the San Siro.
In come Petr Cech, Ainsley Maitland-Niles, Rob Holding, Alex Iwobi, Mohamed Elneny and Pierre-Emerick Aubameyang.
Arsenal: Cech, Maitland Niles, Holding, Mustafi, Kolasinac, Elneny, Xhaka, Ozil, Iwobi, Mkhitaryan, Aubameyang
Watford: Karnezis, Femenia, Prodl, Mariappa, Holebas, Doucoure, Capoue, Janmaat, Pereyra, Richarlison, Deeney
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